enhancer elements การใช้

• Her studies have explored enhancer elements within and between chromosomes.
• He is also recognized for one of the earliest discoveries of a gene enhancer element.
• This can be accomplished through close interactions with core promoter elements, or through the long distance enhancer elements.
• This deletion includes the H2AFY gene, which is responsible for suppressing an upstream enhancer element known as hs1473.
• Transcription factor T acts upstream of BLIMP1 and PRDM4 in PGC specification by binding to the genes respective enhancer elements.
• The regulation of Myf5 is dictated by a large number of enhancer elements that allow a complex system of regulation.
• In 1983, Tonegawa also discovered a transcriptional enhancer element associated with antibody gene complex, the first cellular enhancer element.
• In 1983, Tonegawa also discovered a transcriptional enhancer element associated with antibody gene complex, the first cellular enhancer element.
• It is involved in the signaling pathway and works in conjunction with DLX Dlx5 / 6 enhancer element within neural stem cells.
• In addition to the CMV immediate early enhancer, the intron of the chicken beta actin gene contains an enhancer element, which is highly conserved among vertebrates.
• The first is that there are various inactivating nucleotide variations in the human counterpart of the enhancer element that regulates LPS / IFN-? induced expression of the mouse NOS2 gene.
• Zurich was the site of his work on purification of histone genes, which led to one of the first discoveries of an enhancer element which he termed the " Modulator ".
• These motifs influence the extent to which that region is transcribed into mRNA . Enhancer elements far away from the promoter can also regulate gene expression, through three-dimensional looping interactions.
• These hin binding sites flank the invertible segment which not only encodes the Hin gene itself, but also contains an enhancer element to which the bacterial Fis proteins binds with nanomolar affinity.
• Close to the N terminal end of polyomavirus genome are enhancer elements which induce activation and transcription of a molecule known as the T-antigen ( see SV40 large T-antigen ).
• This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1.
• The 3'UTR contains a translation enhancer element, 3'TE-DR1 that brings about cap independent translation ( a Cap-independent translation element ) and is predicted to have 5 stem loop structures.
• Although the whole construct is commonly referred to as the " CAG promoter ", it is not a promoter in a strict sense, as it includes a part of the transcribed sequence ( two exons and an intron ) and enhancer elements.
• In RNA1 both structural elements within the 3'and 5'UTR are required to translation to occur as the 3'UTR contains the translation enhancer element and the 5'UTR contains structures that aid in recruiting translation factors but also act to increase RNA stability.
• Optimal modulation of both CAF-1 and transcription factor levels increases reprogramming efficiency by several orders of magnitude and facilitated iPS cell formation in as little as 4 days . Mechanistically, CAF-1 suppression led to a more accessible chromatin structure at enhancer elements early during reprogramming.